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Does Isolated Left Bundle Block Cause Heart Failure With Reduced Ejection Fraction? A Retrospective Cohort Study

Alireza Amirzadegan 1 , Kaveh Hosseini 2 , Masih Tajdini 3 , Abdolvahab Baradaran 4 , * and Ali Hosseinsabet 5
Authors Information
1 Associated Professor of Interventional Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
2 Cardiology Resident, Master of Public Health, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
3 Cardiology Resident, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
4 Assistant Professor of Cardiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
5 Assistant Professor of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences , Tehran, Iran
Article information
  • Thrita: , In Press (In Press); e14081
  • Published Online: June 30, 2017
  • Article Type: Research Article
  • Received: January 14, 2017
  • Revised: April 26, 2017
  • Accepted: May 30, 2017
  • DOI: 10.5812/thrita.14081

To Cite: Amirzadegan A, Hosseini K, Tajdini M, Baradaran A, Hosseinsabet A. et al. Does Isolated Left Bundle Block Cause Heart Failure With Reduced Ejection Fraction? A Retrospective Cohort Study, Thrita. Online ahead of Print ;In Press(In Press):e14081. doi: 10.5812/thrita.14081.

Copyright © 2017, Thrita Journal. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Freedman RA, Alderman EL, Sheffield LT, Saporito M, Fisher LD. Bundle branch block in patients with chronic coronary artery disease: angiographic correlates and prognostic significance. J Am Coll Cardiol. 1987;10(1):73-80. [PubMed: 3597997].
  • 2. Ricou F, Nicod P, Gilpin E, Henning H, Ross J. Influence of right bundle branch block on short- and long-term survival after acute anterior myocardial infarction. J Am Coll Cardiol. 1991;17(4):858-63. [PubMed: 1999620].
  • 3. Agrawal H, Zimmerman F, Naheed Z. Isolated left bundle branch block in a toddler. Case Rep Cardiol. 2014;2014:464579. doi: 10.1155/2014/464579. [PubMed: 24963416].
  • 4. Zhang ZM, Rautaharju PM, Prineas RJ, Loehr L, Rosamond W, Soliman EZ. Bundle branch blocks and the risk of mortality in the Atherosclerosis Risk in Communities study. J Cardiovasc Med (Hagerstown). 2016;17(6):411-7. [PubMed: 25575277].
  • 5. Saporito S, van Assen HC, Houthuizen P, Aben JP, Strik M, van Middendorp LB, et al. Assessment of left ventricular mechanical dyssynchrony in left bundle branch block canine model: Comparison between cine and tagged MRI. J Magn Reson Imaging. 2016;44(4):956-63. doi: 10.1002/jmri.25225. [PubMed: 26973138].
  • 6. Vernooy K, Verbeek XA, Peschar M, Crijns HJ, Arts T, Cornelussen RN, et al. Left bundle branch block induces ventricular remodelling and functional septal hypoperfusion. Eur Heart J. 2005;26(1):91-8. doi: 10.1093/eurheartj/ehi008. [PubMed: 15615805].
  • 7. Rotman M, Triebwasser JH. A clinical and follow-up study of right and left bundle branch block. Circulation. 1975;51(3):477-84. [PubMed: 1132086].
  • 8. Fahy GJ, Pinski SL, Miller DP, McCabe N, Pye C, Walsh MJ, et al. Natural history of isolated bundle branch block. Am J Cardiol. 1996;77(14):1185-90. [PubMed: 8651093].
  • 9. Lee SJ, McCulloch C, Mangat I, Foster E, De Marco T, Saxon LA. Isolated bundle branch block and left ventricular dysfunction. J Card Fail. 2003;9(2):87-92. doi: 10.1054/jcaf.2003.19. [PubMed: 12751128].
  • 10. Wassmuth R. Heart failure in patients with normal coronary anatomy: diagnostic algorithm and disease pattern of various etiologies as defined by cardiac MRI. Cardiovasc Diagn Ther. 2012;2(2):128-37. doi: 10.3978/j.issn.2223-3652.2012.04.04. [PubMed: 24282706].
  • 11. Zhang ZM, Rautaharju PM, Soliman EZ, Manson JE, Martin LW, Perez M, et al. Different patterns of bundle-branch blocks and the risk of incident heart failure in the Women's Health Initiative (WHI) study. Circ Heart Fail. 2013;6(4):655-61. doi: 10.1161/CIRCHEARTFAILURE.113.000217. [PubMed: 23729198].
  • 12. Zhang Q, Xue M, Li Z, Wang H, Zhu L, Liu X, et al. Effects of an Isolated Complete Right Bundle Branch Block on Mechanical Ventricular Function. J Ultrasound Med. 2015;34(12):2171-7. doi: 10.7863/ultra.14.10069. [PubMed: 26491093].
  • 13. Blanc JJ, Fatemi M, Bertault V, Baraket F, Etienne Y. Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy with severe heart failure. A new concept of left ventricular dyssynchrony-induced cardiomyopathy. Europace. 2005;7(6):604-10. doi: 10.1016/j.eupc.2005.06.005. [PubMed: 16216764].
  • 14. Littmann L, Symanski JD. Hemodynamic implications of left bundle branch block. J Electrocardiol. 2000;33 Suppl:115-21. [PubMed: 11265710].
  • 15. Schneider JF, Thomas HE, Kreger BE, McNamara PM, Kannel WB. Newly acquired left bundle-branch block: the Framingham study. Ann Intern Med. 1979;90(3):303-10. [PubMed: 154870].
  • 16. Chaudhry U, Platonov PG, Jablonowski R, Couderc JP, Engblom H, Xia X, et al. Evaluation of the ECG based Selvester scoring method to estimate myocardial scar burden and predict clinical outcome in patients with left bundle branch block, with comparison to late gadolinium enhancement CMR imaging. Ann Noninvasive Electrocardiol. 2017. doi: 10.1111/anec.12440. [PubMed: 28248005].
  • 17. Masoudi FA, Havranek EP, Smith G, Fish RH, Steiner JF, Ordin DL, et al. Gender, age, and heart failure with preserved left ventricular systolic function. J Am Coll Cardiol. 2003;41(2):217-23. [PubMed: 12535812].
  • 18. Pan W, Su Y, Zhu W, Shu X, Ge J. Notched QRS complex in lateral leads as a novel predictor of response to cardiac resynchronization therapy. Ann Noninvasive Electrocardiol. 2013;18(2):181-7. doi: 10.1111/anec.12008. [PubMed: 23530489].
  • 19. Hardarson T, Arnason A, Eliasson GJ, Palsson K, Eyjolfsson K, Sigfusson N. Left bundle branch block: prevalence, incidence, follow-up and outcome. Eur Heart J. 1987;8(10):1075-9. [PubMed: 3678236].
  • 20. Baldasseroni S, Opasich C, Gorini M, Lucci D, Marchionni N, Marini M, et al. Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: a report from the Italian network on congestive heart failure. Am Heart J. 2002;143(3):398-405. [PubMed: 11868043].
  • 21. Vaillant C, Martins RP, Donal E, Leclercq C, Thebault C, Behar N, et al. Resolution of left bundle branch block-induced cardiomyopathy by cardiac resynchronization therapy. J Am Coll Cardiol. 2013;61(10):1089-95. doi: 10.1016/j.jacc.2012.10.053. [PubMed: 23352778].
  • 22. Duzenli MA, Ozdemir K, Soylu A, Aygul N, Yazici M, Tokac M. The effect of isolated left bundle branch block on the myocardial velocities and myocardial performance index. Echocardiography. 2008;25(3):256-63. doi: 10.1111/j.1540-8175.2007.00579.x. [PubMed: 18307438].

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Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:


  • Alireza Amirzadegan: [PubMed] []
  • Kaveh Hosseini: [PubMed] []
  • Masih Tajdini: [PubMed] []
  • Abdolvahab Baradaran: [PubMed] []
  • Ali Hosseinsabet: [PubMed] []

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