Published by: Kowsar

The Effect of Postoperative Single-Dose Intravenous Dexamethasone on Common Complications After Tonsillectomy in Children: A Randomized Controlled Trial

Reza Kaboodkhani 1 , Mahmood Shishehgar 1 and Saeid Pourseirafi 1 , *
Authors Information
1 Ear, Nose, Throat Department, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Thrita: March 01, 2016, 5 (1); e32132
  • Published Online: January 23, 2016
  • Article Type: Research Article
  • Received: August 5, 2015
  • Revised: September 10, 2015
  • Accepted: September 10, 2015
  • DOI: 10.5812/thrita.32132

To Cite: Kaboodkhani R, Shishehgar M, Pourseirafi S. The Effect of Postoperative Single-Dose Intravenous Dexamethasone on Common Complications After Tonsillectomy in Children: A Randomized Controlled Trial, Thrita. 2016 ;5(1):e32132. doi: 10.5812/thrita.32132.

Copyright © 2016, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Czarnetzki C, Elia N, Lysakowski C, Dumont L, Landis BN, Giger R, et al. Dexamethasone and risk of nausea and vomiting and postoperative bleeding after tonsillectomy in children: A randomized trial. JAMA. 2008; 300(22): 2621-30[DOI][PubMed]
  • 2. Baugh RF, Archer SM, Mitchell RB, Rosenfeld RM, Amin R, Burns JJ, et al. Clinical practice guideline: Tonsillectomy in children. Otolaryngol Head Neck Surg. 2011; 144(1 Suppl)-30[DOI][PubMed]
  • 3. Mahgoobifard M, Mirmesdagh Y, Imani F, Najafi A, N. M M. The analgesic efficacy of preoperative oral ibuprofen and acetaminophen in children undergoing adenotonsillectomy: A Randomized Clinical Trial. Clin J Pain. 2014; 3(3)[DOI]
  • 4. Hilton M. Tonsillectomy technique-tradition versus technology. The Lancet. 2004; 364(9435): 642-3[DOI]
  • 5. Shah RK, Preciado DA. Re: the efficacy of intravenous or peritonsillar infiltration of ketamine for postoperative pain relief in children following adenotonsillectomy. Paediatr Anaesth. 2007; 17(11): 1114-5[DOI][PubMed]
  • 6. Haddadi S, Marzban S, Karami MS, Heidarzadeh A, Parvizi A, Nabi BN. Comparing the duration of the analgesic effects of intravenous and rectal acetaminophen following tonsillectomy in children. Clin J Pain. 2014; 4(1)
  • 7. Hosseini Jahromi SA, Hosseini Valami SM, Hatamian S. Comparison between effect of lidocaine, morphine and ketamine spray on post-tonsillectomy pain in children. Anesth Pain Med. 2012; 2(1): 17-21[DOI][PubMed]
  • 8. Marret E, Flahault A, Samama CM, Bonnet F. Effects of postoperative, nonsteroidal, antiinflammatory drugs on bleeding risk after tonsillectomy: Meta-analysis of randomized, controlled trials. Anesthesiology. 2003; 98(6): 1497-502[PubMed]
  • 9. Moiniche S, Romsing J, Dahl JRB, Tramer MR. Nonsteroidal Antiinflammatory Drugs and the Risk of Operative Site Bleeding After Tonsillectomy: A Quantitative Systematic Review. Anesth Analg. 2003; 96(1): 68-77[DOI]
  • 10. Aouad MT, Nasr VG, Yazbeck-Karam VG, Bitar MA, Bou Khalil M, Beyrouthy O, et al. A comparison between dexamethasone and methylprednisolone for vomiting prophylaxis after tonsillectomy in inpatient children: A randomized trial. Anesth Analg. 2012; 115(4): 913-20[DOI][PubMed]
  • 11. Muhammad R, Wadood F, Khan MR, Khan Z, Ullah G. Comparison of efficacy of dexamethasone and orogastric suction in reducing post tonsillectomy vomiting in children. GJMS. 2013; 11(1): 54-8
  • 12. Kaan MN, Odabasi O, Gezer E, Daldal A. The effect of preoperative dexamethasone on early oral intake, Vomiting and pain after tonsillectomy. Int J Pediatr Otorhinolaryngol. 2006; 70(1): 73-9[DOI][PubMed]
  • 13. Faiz SH, Rahimzadeh P, Alebouyeh MR, Sedaghat M. A Randomized controlled trial on analgesic effects of intravenous acetaminophen versus dexamethasone after pediatric tonsillectomy. Iran Red Crescent Med J. 2013; 15(11)[DOI][PubMed]
  • 14. Windfuhr JP, Chen YS, Remmert S. Hemorrhage following tonsillectomy and adenoidectomy in 15,218 patients. Otolaryngol Head Neck Surg. 2005; 132(2): 281-6[DOI][PubMed]
  • 15. Safavi M, Honarmand A, Habibabady M, Baraty S, Aghadavoudi O. Assessing intravenous ketamine and intravenous dexamethasone separately and in combination for early oral intake, vomiting and postoperative pain relief in children following tonsillectomy. Medi Arch. 2012; 66(2): 111-5[DOI]
  • 16. Palme CE, Tomasevic P, Pohl DV. Evaluating the effects of oral prednisolone on recovery after tonsillectomy: A prospective, double-blind, randomized trial. Laryngoscope. 2000; 110(12): 2000-4[DOI][PubMed]
  • 17. Carr AS, Courtman S, Holtby H, Morton N, Jacobson S, Brennan L, et al. The association of paediatric anaesthetists of great Britain & Ireland. Guidelines on the prevention of post-operative vomiting in children.; 2009; : 1-35
  • 18. Rhen T, Cidlowski JA. Antiinflammatory action of glucocorticoids-New mechanisms for old drugs. N Engl J Med. 2005; 353(16): 1711-23[DOI][PubMed]
  • 19. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T. Regulation of matrix metalloproteinases: An overview. Mol Cell Biochem. 2003; 253(1-2): 269-85[PubMed]
  • 20. Szabo S, Khomenko T, Gombos Z, Deng XM, Jadus MR, Yoshida M. Review article: transcription factors and growth factors in ulcer healing. Aliment Pharmacol Ther. 2000; 14 Suppl 1: 33-43[PubMed]
  • 21. Durmus M, Karaaslan E, Ozturk E, Gulec M, Iraz M, Edali N, et al. The effects of single-dose Dexamethasone on wound healing in rats. Anesthesia & Analgesia. 2003; : 1377-80[DOI]
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