Published by: Kowsar

Vitamin D Levels in Children With Otitis Media With Effusion: A Case-Control Study

Somaye Hosseini 1 , Mahdi Khajavi 1 , * , Ali Eftekharian 1 and Nader Akbari 1
Authors Information
1 Department of Otorhinolaryngology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Thrita: March 01, 2016, 5 (1); e31977
  • Published Online: January 23, 2016
  • Article Type: Research Article
  • Received: August 7, 2015
  • Revised: September 9, 2015
  • Accepted: September 9, 2015
  • DOI: 10.5812/thrita.31977

To Cite: Hosseini S, Khajavi M, Eftekharian A, Akbari N. Vitamin D Levels in Children With Otitis Media With Effusion: A Case-Control Study, Thrita. 2016 ;5(1):e31977. doi: 10.5812/thrita.31977.

Copyright © 2016, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Erdivanli OC, Coskun ZO, Kazikdas KC, Demirci M. Prevalence of Otitis Media with Effusion among Primary School Children in Eastern Black Sea, in Turkey and the Effect of Smoking in the Development of Otitis Media with Effusion. Indian J Otolaryngol Head Neck Surg. 2012; 64(1): 17-21[DOI][PubMed]
  • 2. Bluestone CD, Stephenson JS, Martin LM. Ten-year review of otitis media pathogens. Pediatr Infect Dis J. 1992; 11(8 Suppl)-11[PubMed]
  • 3. Poe DS, Abou-Halawa A, Abdel-Razek O. Analysis of the Dysfunctional Eustachian Tube by Video Endoscopy. Otol Neurotol J. 2001; 22(5): 590-5[DOI]
  • 4. Bhat V, Bhandary SK, Shenoy V. Otitis media with effusion in relation to socio economic status: a community based study. Indian J Otolaryngol Head Neck Surg. 2012; 64(1): 56-8[DOI][PubMed]
  • 5. Kubba H, Pearson JP, Birchall JP. The aetiology of otitis media with effusion: a review. Clin Otolaryngol Allied Sci. 2000; 25(3): 181-94[PubMed]
  • 6. Pichichero ME, Reiner SA, Brook I, Gooch 3rd WM, Yamauchi T, Jenkins SG, et al. Controversies in the medical management of persistent and recurrent acute otitis media. Recommendations of a clinical advisory committee. Ann Otol Rhinol Laryngol Suppl. 2000; 183: 1-12[PubMed]
  • 7. Ashhurst-Smith C, Hall ST, Burns CJ, Stuart J, Blackwell CC. In vitro inflammatory responses elicited by isolates of Alloiococcus otitidis obtained from children with otitis media with effusion. Innate Immun. 2014; 20(3): 320-6[DOI][PubMed]
  • 8. Cayir A, Turan MI, Ozkan O, Cayir Y, Kaya A, Davutoglu S, et al. Serum vitamin D levels in children with recurrent otitis media. Eur Arch Otorhinolaryngol. 2014; 271(4): 689-93[DOI][PubMed]
  • 9. Marchisio P, Consonni D, Baggi E, Zampiero A, Bianchini S, Terranova L, et al. Vitamin D supplementation reduces the risk of acute otitis media in otitis-prone children. Pediatr Infect Dis J. 2013; 32(10): 1055-60[DOI][PubMed]
  • 10. Mulligan JK, White DR, Wang EW, Sansoni SR, Moses H, Yawn RJ, et al. Vitamin D3 deficiency increases sinus mucosa dendritic cells in pediatric chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg. 2012; 147(4): 773-81[DOI][PubMed]
  • 11. Rovers M, Haggard M, Gannon M, Koeppen-Schomerus G, Plomin R. Heritability of symptom domains in otitis media: a longitudinal study of 1,373 twin pairs. Am J Epidemiol. 2002; 155(10): 958-64[PubMed]
  • 12. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009; 20(11): 1807-20[DOI][PubMed]
  • 13. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008; 87(4): 1080S-6S[PubMed]
  • 14. McGill AT, Stewart JM, Lithander FE, Strik CM, Poppitt SD. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity. Nutr J. 2008; 7: 4[DOI][PubMed]
  • 15. Timms PM, Mannan N, Hitman GA, Noonan K, Mills PG, Syndercombe-Court D, et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM. 2002; 95(12): 787-96[PubMed]
  • 16. Sabetta JR, DePetrillo P, Cipriani RJ, Smardin J, Burns LA, Landry ML. Serum 25-hydroxyvitamin d and the incidence of acute viral respiratory tract infections in healthy adults. PLoS One. 2010; 5(6)[DOI][PubMed]
  • 17. Androw F, Inglis JR, Gates A. Acute otitis media and otitis media with effusion. In: Cummings CW. Cummings otolaryngology head and neck surgery. 2005; : 4445-68
  • 18. Linday LA, Shindledecker RD, Dolitsky JN, Chen TC, Holick MF. Plasma 25-Hydroxyvitamin D Levels in Young Children Undergoing Placement of Tympanostomy Tubes. Rhinol Laryngol J. 2008; 117(10): 740-4[DOI]
  • 19. Cayir A, Turan MI, Ozkan O, Cayir Y. Vitamin D levels in children diagnosed with acute otitis media. J Pak Med Assoc. 2014; 64(11): 1274-7[PubMed]
  • 20. Hashemipour S, Larijani B, Adibi H, Javadi E, Sedaghat M, Pajouhi M, et al. Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health. 2004; 4: 38[DOI][PubMed]
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