Published by: Kowsar

Comparing Effects of Arnebia euchroma and Alpha Ointment on Wound Healing Process

Maryam Mohsenikia 1 , Hasti Nuraei 2 , Fatemeh Karimi 2 , Neda Jamalnia 2 , Soheil Ashkani Esfahani 2 , * , Shima Rafiee 2 , Zahra Azizian 3 and Alireza Moradi 4
Authors Information
1 Young Researchers and Elite Club, Tehran Medical Branch, Islamic Azad University, Tehran, IR Iran
2 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Department of Dermatology, Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, IR Iran
4 Student Research Committee, Qom University of Medical Sciences, Qom, IR Iran
Article information
  • Thrita: March 01, 2015, 4 (1); e25781
  • Published Online: January 10, 2015
  • Article Type: Research Article
  • Received: December 5, 2014
  • Accepted: December 6, 2014
  • DOI: 10.5812/thrita.25781

To Cite: Mohsenikia M, Nuraei H, Karimi F, Jamalnia N, Ashkani Esfahani S, et al. Comparing Effects of Arnebia euchroma and Alpha Ointment on Wound Healing Process, Thrita. 2015 ;4(1):e25781. doi: 10.5812/thrita.25781.

Copyright © 2015, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Guo S, Dipietro LA. Factors affecting wound healing. J Dent Res. 2010; 89(3): 219-29[DOI][PubMed]
  • 2. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999; 341(10): 738-46[DOI][PubMed]
  • 3. Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen. 2009; 17(2): 153-62[DOI][PubMed]
  • 4. Ansari M, Farzin D, Mosalaei A, Omidvari S, Ahmadloo N, Mohammadianpanah M. Efficacy of topical alpha ointment (containing natural henna) compared to topical hydrocortisone (1%) in the healing of radiation-induced dermatitis in patients with breast cancer: a randomized controlled clinical trial. Iran J Med Sci. 2013; 38(4): 293-300[PubMed]
  • 5. Maddocks-Jennings W, Wilkinson JM, Shillington D. Novel approaches to radiotherapy-induced skin reactions: a literature review. Complement Ther Clin Pract. 2005; 11(4): 224-31[DOI][PubMed]
  • 6. Guha G, Rajkumar V, Kumar RA, Mathew L. Antioxidant Activity of Lawsonia inermis Extracts Inhibits Chromium(VI)-Induced Cellular and DNA Toxicity. Evid Based Complement Alternat Med. 2011; 2011: 576456[DOI][PubMed]
  • 7. Liu H, Jin YS, Song Y, Yang XN, Yang XW, Geng DS, et al. Three new compounds from Arnebia euchroma. J Asian Nat Prod Res. 2010; 12(4): 286-92[DOI][PubMed]
  • 8. Kaith BS, Kaith NS, Chauhan NS. Anti-inflammatory effect of Arnebia euchroma root extracts in rats. J Ethnopharmacol. 1996; 55(1): 77-80[PubMed]
  • 9. Shen CC, Syu WJ, Li SY, Lin CH, Lee GH, Sun CM. Antimicrobial activities of naphthazarins from Arnebia euchroma. J Nat Prod. 2002; 65(12): 1857-62[DOI][PubMed]
  • 10. You YJ, Kim Y, Song GY, Ahn BZ. (E) -6-(1-alkyloxyiminoalkyl)-5,8-dimethoxy-1,4-naphthoquinones: synthesis, cytotoxic activity and antitumor activity. Bioorg Med Chem Lett. 2000; 10(20): 2301-3[PubMed]
  • 11. Atiyeh BS, Costagliola M, Hayek SN, Dibo SA. Effect of silver on burn wound infection control and healing: review of the literature. Burns. 2007; 33(2): 139-48[DOI][PubMed]
  • 12. Annan K, Houghton PJ. Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana. J Ethnopharmacol. 2008; 119(1): 141-4[DOI][PubMed]
  • 13. Ashkani-Esfahani S, Imanieh MH, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, et al. The healing effect of arnebia euchroma in second degree burn wounds in rat as an animal model. Iran Red Crescent Med J. 2012; 14(2): 70-4[PubMed]
  • 14. Ashkani-Esfahani S, Imanieh MH, Meshksar A, Khoshneviszadeh M, Noorafshan A, Geramizadeh B, et al. Enhancement of Fibroblast Proliferation, Vascularization and Collagen Synthesis in the Healing Process of Third-Degree Burn Wounds by Topical Arnebia euchroma, a Herbal Medicine. Galen Med J. 2013; 1(2): 53-9
  • 15. Karayannopoulou M, Tsioli V, Loukopoulos P, Anagnostou TL, Giannakas N, Savvas I, et al. Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog. Can J Vet Res. 2011; 75(1): 42-8[PubMed]
  • 16. Tanaka S, Tajima M, Tsukada M, Tabata M. A comparative study on anti-inflammatory activities of the enantiomers, shikonin and alkannin. J Nat Prod. 1986; 49(3): 466-9[PubMed]
  • 17. Pirbalouti AG, Yousefi M, Nazari H, Karimi I, Koohpayeh A. Evaluation of burn healing properties of Arnebia euchroma and Malva sylvestris. Electron J Biol. 2009; 5(3): 62-6
  • 18. Sidhu GS, Singh AK, Banaudha KK, Gaddipati JP, Patnaik GK, Maheshwari RK. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999; 113(5): 773-81[DOI][PubMed]
  • 19. Nayak BS, Isitor G, Davis EM, Pillai GK. The evidence based wound healing activity of Lawsonia inermis Linn. Phytother Res. 2007; 21(9): 827-31[DOI][PubMed]
  • 20. Hosseini SV, Tanideh N, Kohanteb J, Ghodrati Z, Mehrabani D, Yarmohammadi H. Comparison between Alpha and silver sulfadiazine ointments in treatment of Pseudomonas infections in 3rd degree burns. Int J Surg. 2007; 5(1): 23-6[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments