Published by: Kowsar

Biochemical Interfering Factors and Blood Cells Indices

Hosnie Hosseini 1 , Akbar Dorgalaleh 2 , * , Shadi Tabibian 2 , Meysam Kashiri 2 , Esmaeil Sanei Moghaddam 3 , Shaban Alizadeh 2 , Taregh Bamedi 4 , Samira Esmaeili Reykande 2 and Saeed Dorgalaleh 5
Authors Information
1 Department of Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Zahedan Branch, Zahedan, IR Iran
2 Hematology Department, Allied Medical School, Tehran University of Medical Sciences, Tehran, IR Iran
3 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Zahedan, IR Iran
4 Zahedan Regional Educational Blood Transfusion Center, Zahedan, IR Iran
5 Medical Laboratory Sciences, Zabol University of Medical Sciences, Zabol, IR Iran
Article information
  • Thrita: March 01, 2014, 3 (1); e15516
  • Published Online: March 2, 2014
  • Article Type: Brief Report
  • Received: October 20, 2013
  • Revised: November 11, 2013
  • Accepted: December 7, 2013
  • DOI: 10.5812/thrita.15516

To Cite: Hosseini H, Dorgalaleh A, Tabibian S, Kashiri M, Sanei Moghaddam E, et al. Biochemical Interfering Factors and Blood Cells Indices, Thrita. 2014 ;3(1):e15516. doi: 10.5812/thrita.15516.

Copyright © 2014, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Kickler TS. Clinical Analyzers. Advances in Automated Cell Counting. Anal Chem. 1999; 71(12): 363-5[DOI]
  • 2. Weiss DJ. Application of flow cytometric techniques to veterinary clinical hematology. Vet Clin Pathol. 2002; 31(2): 72-82[PubMed]
  • 3. Zandecki M, Genevieve F, Gerard J, Godon A. Spurious counts and spurious results on haematology analysers: a review. Part II: white blood cells, red blood cells, haemoglobin, red cell indices and reticulocytes. Int J Lab Hematol. 2007; 29(1): 21-41[DOI][PubMed]
  • 4. DeNicola DB. Advances in hematology analyzers. Top Companion Anim Med. 2011; 26(2): 52-61[DOI][PubMed]
  • 5. Kazmierczak SC, Catrou PG. Analytical interference. More than just a laboratory problem. Am J Clin Pathol. 2000; 113(1): 9-11[DOI][PubMed]
  • 6. Kroll MH, Elin RJ. Interference with clinical laboratory analyses. Clin Chem. 1994; 40(11 Pt 1): 1996-2005[PubMed]
  • 7. Chait A, Brunzell JD. Acquired hyperlipidemia (secondary dyslipoproteinemias). Endocrinol Metab Clin North Am. 1990; 19(2): 259-78[PubMed]
  • 8. Kroll MH. Evaluating interference caused by lipemia. Clin Chem. 2004; 50(11): 1968-9[DOI][PubMed]
  • 9. Sadeghian MH. Correlation Between Hyperlipemia and Erythrocytes Indexes. Int J Hematol Oncol. 2008; 18(3): 150-4
  • 10. Cicha I, Suzuki Y, Tateishi N, Maeda N. Enhancement of red blood cell aggregation by plasma triglycerides. Clin Hemorheol Microcirc. 2001; 24(4): 247-55[PubMed]
  • 11. Giugliano D, Ceriello A, Esposito K. Glucose metabolism and hyperglycemia. Am J Clin Nutr. 2008; 87(1): 217S-22S[PubMed]
  • 12. Planas AT, Van Voolen GA, Kelly LA. Hyperglycemic macrocytosis in electronically determined mean corpuscular volume. Use of three different automatic cell counters. Ann Clin Lab Sci. 1985; 15(4): 286-91[PubMed]
  • 13. Strauchen JA, Alston W, Anderson J, Gustafson Z, Fajardo LF. Inaccuracy in automated measurement of hematocrit and corpuscular indices in the presence of severe hyperglycemia. Blood. 1981; 57(6): 1065-7[PubMed]
  • 14. Meyer TW, Hostetter TH. Uremia. N Engl J Med. 2007; 357(13): 1316-25[DOI][PubMed]
  • 15. Steen G, Vermeer HJ, Naus AJ, Goevaerts B, Agricola PT, Schoenmakers CH. Multicenter evaluation of the interference of hemoglobin, bilirubin and lipids on Synchron LX-20 assays. Clin Chem Lab Med. 2006; 44(4): 413-9[DOI][PubMed]
  • 16. Sandberg S, Sonstabo K, Christensen NG. Influence of lipid and leukocytes on the haemoglobin determination by Coulter Counter S Plus III, Technicon H 6000, Technicon H 1, LK 540, Reflotron and Hemocap. Scand J Clin Lab Invest. 1989; 49(2): 145-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments