Published by: Kowsar

The Effects of Olive Leaf Extract on Antioxidant Enzymes Activity and Tumor Growth in Breast Cancer

Sarah Milanizadeh 1 , Mohammad Reza Bigdeli 1 , * , Bahram Rasoulian 2 and Davar Amani 3
Authors Information
1 Physiology Department, Faculty of Biological Sciences, Shahid Beheshti University, General Campus, Tehran, IR Iran
2 Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, IR Iran
3 Immunology Department, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Thrita: March 01, 2014, 3 (1); e12914
  • Published Online: February 27, 2014
  • Article Type: Research Article
  • Received: June 19, 2013
  • Revised: September 15, 2013
  • Accepted: October 17, 2013
  • DOI: 10.5812/thrita.12914

To Cite: Milanizadeh S, Bigdeli M R, Rasoulian B, Amani D. The Effects of Olive Leaf Extract on Antioxidant Enzymes Activity and Tumor Growth in Breast Cancer, Thrita. 2014 ;3(1):e12914. doi: 10.5812/thrita.12914.

Copyright © 2014, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Keys A. Seven countries: A multivariate analysis of death and coronary heart disease. 1980;
  • 2. Serra-Majem L, Roman B, Estruch R. Scientific evidence of interventions using the Mediterranean diet: a systematic review. Nutr Rev. 2006; 64(2 Pt 2)-47[PubMed]
  • 3. Trichopoulou A, Naska A, Orfanos P, Trichopoulos D. Mediterranean diet in relation to body mass index and waist-to-hip ratio: the Greek European Prospective Investigation into Cancer and Nutrition Study. Am J Clin Nutr. 2005; 82(5): 935-40[PubMed]
  • 4. Orlikova B, Diederich M. Power from the garden: plant compounds as inhibitors of the hallmarks of cancer. Curr Med Chem. 2012; 19(14): 2061-87[PubMed]
  • 5. Schumacher M, Kelkel M, Dicato M, Diederich M. Gold from the sea: marine compounds as inhibitors of the hallmarks of cancer. Biotechnol Adv. 2011; 29(5): 531-47[DOI][PubMed]
  • 6. Mates JM, Perez-Gomez C, Nunez de Castro I. Antioxidant enzymes and human diseases. Clin Biochem. 1999; 32(8): 595-603[PubMed]
  • 7. Adetoro KO, Bolanle JD, Abdullahi SB, Ahmed OA, Makun HA. In vivo antioxidant effect of aqueous root bark, stem bark and leaves extracts of Vitex doniana in CCl4 induced liver damage rats. Asian Pac J Trop Biomed. 2013; 3(5): 395-400[DOI][PubMed]
  • 8. Chopra S, Wallace HM. Induction of spermidine/spermine N1-acetyltransferase in human cancer cells in response to increased production of reactive oxygen species. Biochem Pharmacol. 1998; 55(7): 1119-23[PubMed]
  • 9. Wojtaszek P. Oxidative burst: an early plant response to pathogen infection. Biochem J. 1997; 322 ( Pt 3): 681-92[PubMed]
  • 10. Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg. 2006; 391(5): 499-510[DOI][PubMed]
  • 11. Tsutsui H, Ide T, Kinugawa S. Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxid Redox Signal. 2006; 8(9-10): 1737-44[DOI][PubMed]
  • 12. Sheweita SA, Tilmisany AK. Cancer and phase II drug-metabolizing enzymes. Curr Drug Metab. 2003; 4(1): 45-58[PubMed]
  • 13. Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, et al. CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene. 2005; 24(3): 367-80[DOI][PubMed]
  • 14. Plymate SR, Haugk KH, Sprenger CC, Nelson PS, Tennant MK, Zhang Y, et al. Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1. Oncogene. 2003; 22(7): 1024-34[DOI][PubMed]
  • 15. Aggarwal S, Subberwal M, Kumar S, Sharma M. Brain tumor and role of beta-carotene, a-tocopherol, superoxide dismutase and glutathione peroxidase. J Cancer Res Ther. 2006; 2(1): 24-7[PubMed]
  • 16. Wilcox CS. Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Pharmacol Ther. 2010; 126(2): 119-45[DOI][PubMed]
  • 17. de Haan JB, Cristiano F, Iannello R, Bladier C, Kelner MJ, Kola I. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum Mol Genet. 1996; 5(2): 283-92[PubMed]
  • 18. Okada F, Shionoya H, Kobayashi M, Kobayashi T, Tazawa H, Onuma K, et al. Prevention of inflammation-mediated acquisition of metastatic properties of benign mouse fibrosarcoma cells by administration of an orally available superoxide dismutase. Br J Cancer. 2006; 94(6): 854-62[DOI][PubMed]
  • 19. Chung-man Ho J, Zheng S, Comhair SA, Farver C, Erzurum SC. Differential expression of manganese superoxide dismutase and catalase in lung cancer. Cancer Res. 2001; 61(23): 8578-85[PubMed]
  • 20. Mason EE, Chin TF, Li YW, Ziffren SE. Cancer and human liver catalase. Cancer Res. 1960; 20: 1474-81[PubMed]
  • 21. Surapaneni KM, Gopan CS. Status of lipid peroxidation and antioxidant enzymes in patients with carcinoma of breast. JMSR. 2007; 15: 21-4
  • 22. Khan MA, Tania M, Zhang D, Chen H. Antioxidant enzymes and cancer. Chin J Cancer Res. 2010; 22(2): 87-92
  • 23. Khan N, Sultana S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Eur J Cancer Prev. 2005; 14(2): 159-68[PubMed]
  • 24. Omar SH. Oleuropein in olive and its pharmacological effects. Sci Pharm. 2010; 78(2): 133-54[DOI][PubMed]
  • 25. Han J, Talorete TP, Yamada P, Isoda H. Anti-proliferative and apoptotic effects of oleuropein and hydroxytyrosol on human breast cancer MCF-7 cells. Cytotechnology. 2009; 59(1): 45-53[DOI][PubMed]
  • 26. Corona G, Deiana M, Incani A, Vauzour D, Dessi MA, Spencer JP. Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects. Biochem Biophys Res Commun. 2007; 362(3): 606-11[DOI][PubMed]
  • 27. Mohagheghi F, Bigdeli MR, Rasoulian B, Hashemi P, Pour MR. The neuroprotective effect of olive leaf extract is related to improved blood-brain barrier permeability and brain edema in rat with experimental focal cerebral ischemia. Phytomedicine. 2011; 18(2-3): 170-5[DOI][PubMed]
  • 28. Hassan ZM, Yaraee R, Zare N, Ghazanfari T, Sarraf Nejad AH, Nazori B. Immunomodulatory affect of R10 fraction of garlic extract on natural killer activity. Int Immunopharmacol. 2003; 3(10-11): 1483-9[DOI][PubMed]
  • 29. Singh SV, Mohan RR, Agarwal R, Benson PJ, Hu X, Rudy MA, et al. Novel anti-carcinogenic activity of an organosulfide from garlic: inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing. Biochem Biophys Res Commun. 1996; 225(2): 660-5[DOI][PubMed]
  • 30. Bigdeli MR, Rasoulian B, Meratan AA. In vivo normobaric hyperoxia preconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue. Eur J Pharmacol. 2009; 611(1-3): 22-9[DOI][PubMed]
  • 31. Hernandez-Ramirez RU, Galvan-Portillo MV, Ward MH, Agudo A, Gonzalez CA, Onate-Ocana LF, et al. Dietary intake of polyphenols, nitrate and nitrite and gastric cancer risk in Mexico City. Int J Cancer. 2009; 125(6): 1424-30[DOI][PubMed]
  • 32. Smolarek AK, Suh N. Chemopreventive activity of vitamin E in breast cancer: a focus on gamma- and delta-tocopherol. Nutrients. 2011; 3(11): 962-86[DOI][PubMed]
  • 33. Lambert JD, Elias RJ. The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys. 2010; 501(1): 65-72[DOI][PubMed]
  • 34. Wen W, Lu J, Zhang K, Chen S. Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway. Cancer Prev Res (Phila). 2008; 1(7): 554-61[DOI][PubMed]
  • 35. Choi SK, Zhang XH, Seo JS. Suppression of oxidative stress by grape seed supplementation in rats. Nutr Res Pract. 2012; 6(1): 3-8[DOI][PubMed]
  • 36. Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem. 2006; 54(3): 980-5[DOI][PubMed]
  • 37. Kohno H, Suzuki R, Yasui Y, Hosokawa M, Miyashita K, Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci. 2004; 95(6): 481-6[PubMed]
  • 38. Rabiei Z, Bigdeli MR, Rasoulian B, Ghassempour A, Mirzajani F. The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model. Phytomedicine. 2012; 19(10): 940-6[DOI][PubMed]
  • 39. de Bock M, Derraik JG, Brennan CM, Biggs JB, Morgan PE, Hodgkinson SC, et al. Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial. PLoS One. 2013; 8(3)[DOI][PubMed]
  • 40. Fares R, Bazzi S, Baydoun SE, Abdel-Massih RM. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant Foods Hum Nutr. 2011; 66(1): 58-63[DOI][PubMed]
  • 41. Warleta F, Quesada CS, Campos M, Allouche Y, Beltran G, Gaforio JJ. Hydroxytyrosol protects against oxidative DNA damage in human breast cells. Nutrients. 2011; 3(10): 839-57[DOI][PubMed]
  • 42. Oliveras-Lopez MJ, Molina JJ, Mir MV, Rey EF, Martin F, de la Serrana HL. Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans. Arch Gerontol Geriatr. 2013; 57(2): 234-42[DOI][PubMed]
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