Published by: Kowsar

Assessment of the Effects of Protein Malnutrition on Cerebellar Purkinje Cells in Adult Rats

Gholamreza Hassanzadeh 1 , 3 , Fatemeh Attari 2 , 3 , * , Mahnaz Azarnia 4 , Seyed Mohammad Hossein Noori Mogahi 1 , Hamid Hamdollah Zadeh 4 , Maryam Javadi 5 , Rostam Ghorbani 6 and Alireza Karambaksh 1
Authors Information
1 Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran
2 Shefa Neuroscience Research Center, Khatamolanbia Hospital, Tehran, IR Iran
3 Department of Neuroscience, School of Advanced Medical Technology, Tehran University of Medical Sciences, Tehran, IR Iran
4 Department of Biology, Faculty of Science, Kharazmi University of Tehran, Tehran, IR Iran
5 Department of Nutrition and Dietary Therapy, School of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
6 Department of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IR Iran
Article information
  • Thrita: September 6, 2013, 2 (3); 6-9
  • Published Online: August 26, 2013
  • Article Type: Research Article
  • Received: July 19, 2012
  • Revised: September 20, 2012
  • Accepted: December 22, 2012
  • DOI: 10.5812/thrita.7272

To Cite: Hassanzadeh G, Attari F, Azarnia M, Noori Mogahi S M H, Hamdollah Zadeh H, et al. Assessment of the Effects of Protein Malnutrition on Cerebellar Purkinje Cells in Adult Rats, Thrita. 2013 ;2(3):6-9. doi: 10.5812/thrita.7272.

Copyright © 2013, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Slemmer JE, De Zeeuw CI, Weber JT. Don't get too excited: mechanisms of glutamate-mediated Purkinje cell death. Prog Brain Res. 2005; 148: 367-90[DOI][PubMed]
  • 2. Schmolesky MT, De Zeeuw CI, Hansel C. Climbing fiber synaptic plasticity and modifications in Purkinje cell excitability. Prog Brain Res. 2005; 148: 81-94[DOI][PubMed]
  • 3. Hassanzadeh G, Bayat M, Javadi M. Effect of Protein Malnutrition on Efferent Projections of Amygdala to the Hippocampus. Basic Clin Neurosci. 2010; 2(1): 37-43
  • 4. Console GM, Jurado SB, Oyhenart E, Ferese C, Pucciarelli H, Gomez Dumm CL. Morphometric and ultrastructural analysis of different pituitary cell populations in undernourished monkeys. Braz J Med Biol Res. 2001; 34(1): 65-74[PubMed]
  • 5. Perry ML, Gamallo JL, Bernard EA. Effect of protein malnutrition on glycoprotein synthesis in rat cerebral cortex slices during the period of brain growth spurt. J Nutr. 1986; 116(12): 2486-9[PubMed]
  • 6. Okoshi MP, Okoshi K, Pai VD, Pai-Silva MD, Matsubara LS, Cicogna AC. Mechanical, biochemical, and morphological changes in the heart from chronic food-restricted rats. Can J Physiol Pharm . 2001; 79(9): 754-760[DOI]
  • 7. Rotta LN, Schmidt AP, Mello e Souza T, Nogueira CW, Souza KB, Izquierdo IA, et al. Effects of undernutrition on glutamatergic parameters in rat brain. Neurochem Res. 2003; 28(8): 1181-6[PubMed]
  • 8. Giuffrida AM, Hamberger A, Serra I, Geremia E. Effects of undernutrition on nucleic acid synthesis in neuronal and glial cells from different regions of developing rat brain. Nutr Metab. 1980; 24(3): 189-98[PubMed]
  • 9. Effects of prenatal protein malnutrition on excitatory aminoacids receptors in rat hippocampus, entorhinal cortex, and neocortex. Soc. Neurosci. : 94
  • 10. Telang S, Fuller G, Wiggins R, Enna SJ. Early undernutrition and [3H]gamma-aminobutyric acid binding in rat brain. J Neurochem. 1984; 43(3): 640-5[PubMed]
  • 11. Singh TD, Shankar R. Developmental regulation and effect of early undernutrition on phosphorylation of rat cortical synaptic membrane proteins. Int J Dev Neurosci. 1999; 17(7): 743-51[PubMed]
  • 12. Hackett R, Iype T. Malnutrition and childhood epilepsy in developing countries. Seizure. 2001; 10(8): 554-8[DOI][PubMed]
  • 13. Manocha SL, Olkowski ZL. Experimental protein malnutrition in primates--cytochemistry of the nervous system. Am J Phys Anthropol. 1973; 38(2): 439-45[DOI][PubMed]
  • 14. Ranade SC, Sarfaraz Nawaz M, Kumar Rambtla P, Rose AJ, Gressens P, Mani S. Early protein malnutrition disrupts cerebellar development and impairs motor coordination. Br J Nutr. 2012; 107(8): 1167-75[DOI][PubMed]
  • 15. Feoli AM, Siqueira IR, Almeida L, Tramontina AC, Vanzella C, Sbaraini S, et al. Effects of protein malnutrition on oxidative status in rat brain. Nutrition. 2006; 22(2): 160-5[DOI][PubMed]
  • 16. Stern WC, Forbes WB, Resnick O, Morgane PJ. Seizure susceptibility and brain amine levels following protein malnutrition during development in the rat. Brain Res. 1974; 79(3): 375-84[PubMed]
  • 17. Manocha SL, Olkowski Z. Experimental protein malnutrition in primates: cytochemical studies on the cerebellum of the squirrel monkey, Saimiri sciureus. Histochem J. 1973; 5(2): 105-18[PubMed]
  • 18. Fish I, Winick M. Effect of malnutrition on regional growth of the developing rat brain. Exp Neurol. 1969; 25(4): 534-40[PubMed]
  • 19. Andrade JP, Paula-Barbosa MM. Protein malnutrition alters the cholinergic and GABAergic systems of the hippocampal formation of the adult rat: an immunocytochemical study. Neurosci Lett. 1996; 211(3): 211-5[PubMed]
  • 20. Garcia-Ruiz M, Diaz-Cintra S, Cintra L, Corkidi G. Effect of protein malnutrition on CA3 hippocampal pyramidal cells in rats of three ages. Brain Res. 1993; 625(2): 203-12[PubMed]
  • 21. Desai M, Crowther NJ, Lucas A, Hales CN. Organ-selective growth in the offspring of protein-restricted mothers. Br J Nutr. 1996; 76(4): 591-603[PubMed]
  • 22. Andrade JP, Lukoyanov NV, Paula-Barbosa MM. Chronic food restriction is associated with subtle dendritic alterations in granule cells of the rat hippocampal formation. Hippocampus. 2002; 12(2): 149-64[DOI][PubMed]
  • 23. Mokler DJ, Bronzino JD, Galler JR, Morgane PJ. The effects of median raphe electrical stimulation on serotonin release in the dorsal hippocampal formation of prenatally protein malnourished rats. Brain Res. 1999; 838(1-2): 95-103[PubMed]
  • 24. Soto-Moyano R, Fernandez V, Sanhueza M, Belmar J, Kusch C, Perez H, et al. Effects of mild protein prenatal malnutrition and subsequent postnatal nutritional rehabilitation on noradrenaline release and neuronal density in the rat occipital cortex. Brain Res Dev Brain Res. 1999; 116(1): 51-8[PubMed]
  • 25. Azzolin IR, Bernard EA, Trindade VM, Gamallo JL, Perry ML. Effect of protein malnutrition on glycoprotein, protein and lipid synthesis in the rat cerebellum during the period of brain growth spurt. Ann Nutr Metab. 1991; 35(2): 82-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments