Published by: Kowsar

Antiepileptic Effect of Vitamin E on Kainic Acid-induced Temporal Lobe Epilepsy in Rats

Zahra Kiasalari 1 , * , Mehrdad Roghani 1 , Mohsen Khalili 1 and Samaneh Shafii 1
Authors Information
1 Department of physiology, School of Medicine and Neurophysiology Research Center, Shahed University, Tehran, IR Iran
Article information
  • Thrita: September 10, 2012, 1 (1); 27-9
  • Published Online: September 1, 2012
  • Article Type: Research Article
  • Received: August 17, 2011
  • Revised: September 11, 2011
  • Accepted: November 5, 2011
  • DOI: 10.5812/thrita.4265

To Cite: Kiasalari Z, Roghani M, Khalili M, Shafii S. Antiepileptic Effect of Vitamin E on Kainic Acid-induced Temporal Lobe Epilepsy in Rats, Thrita. 2012 ;1(1):27-9. doi: 10.5812/thrita.4265.

Copyright © 2012, Thrita. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Banerjee PN, Filippi D, Allen Hauser W. The descriptive epidemiology of epilepsy-a review. Epilepsy Res. 2009; 85(1): 31-45[DOI][PubMed]
  • 2. Dichter MA. Emerging concepts in the pathogenesis of epilepsy and epileptogenesis. Arch Neurol. 2009; 66(4): 443-7[DOI][PubMed]
  • 3. Asconape JJ. The selection of antiepileptic drugs for the treatment of epilepsy in children and adults. Neurol Clin. 2010; 28(4): 843-52[DOI][PubMed]
  • 4. Cao L, Chen R, Xu J, Lin Y, Wang R, Chi Z. Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus. Neuroscience. 2009; 161(1): 73-7[DOI][PubMed]
  • 5. Naziroglu M, Kutluhan S, Uguz AC, Celik O, Bal R, Butterworth PJ. Topiramate and vitamin e modulate the electroencephalographic records, brain microsomal and blood antioxidant redox system in pentylentetrazol-induced seizure of rats. J Membr Biol. 2009; 229(3): 131-40[DOI][PubMed]
  • 6. Ayyildiz M, Yildirim M, Agar E. The effects of vitamin E on penicillin-induced epileptiform activity in rats. Exp Brain Res. 2006; 174(1): 109-13[DOI][PubMed]
  • 7. Gupta RC, Milatovic D, Zivin M, Dettbarn WD. Seizure-induced changes in energy metabolites and effects of N-tert-butyl-alpha-phenylnitrone (PNB) and vitamin E in rats. Pflugers Arch. 2000; 440(5 Suppl)-2[PubMed]
  • 8. Racine Ronald J. Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology. 1972; 32(3): 281-294
  • 9. Shi X, Yao BZ, Liu D. [Lipoprotein lipase expression in the hippocampus and its effects on vitamin E levels in rats with epilepsy]. Zhongguo Dang Dai Er Ke Za Zhi. 2010; 12(5): 377-81[PubMed]
  • 10. Hoshida S, Hatano M, Furukawa M, Ito M. Neuroprotective effects of vitamin E on adult rat motor neurones following facial nerve avulsion. Acta Otolaryngol. 2009; 129(3): 330-6[DOI][PubMed]
  • 11. Khanna S, Roy S, Slivka A, Craft TK, Chaki S, Rink C, et al. Neuroprotective properties of the natural vitamin E alpha-tocotrienol. Stroke. 2005; 36(10): 2258-64[DOI][PubMed]
  • 12. Larnaout A, Belal S, Zouari M, Fki M, Ben Hamida C, Goebel HH, et al. Friedreich's ataxia with isolated vitamin E deficiency: a neuropathological study of a Tunisian patient. Acta Neuropathol. 1997; 93(6): 633-7[PubMed]
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